(13)C-metabolic flux analysis in S-adenosyl-L-methionine production by Saccharomyces cerevisiae.

@article{Hayakawa201513CmetabolicFA,
  title={(13)C-metabolic flux analysis in S-adenosyl-L-methionine production by Saccharomyces cerevisiae.},
  author={Kenshi Hayakawa and Shuichi Kajihata and Fumio Matsuda and Hiroshi Shimizu},
  journal={Journal of bioscience and bioengineering},
  year={2015},
  volume={120 5},
  pages={532-8}
}
S-Adenosyl-L-methionine (SAM) is a major biological methyl group donor, and is used as a nutritional supplement and prescription drug. Yeast is used for the industrial production of SAM owing to its high intracellular SAM concentrations. To determine the regulation mechanisms responsible for such high SAM production, (13)C-metabolic flux analysis ((13)C-MFA) was conducted to compare the flux distributions in the central metabolism between Kyokai no. 6 (high SAM-producing) and S288C (control… CONTINUE READING
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