(10E,12Z)-9-Hydroxy-10,12-octadecadiensäure, ein Aromatase-Hemmstoff aus dem Wurzelextrakt von Urtica dioica

@inproceedings{Kraus199110E12Z9Hydroxy1012octadecadiensureEA,
  title={(10E,12Z)-9-Hydroxy-10,12-octadecadiens{\"a}ure, ein Aromatase-Hemmstoff aus dem Wurzelextrakt von Urtica dioica},
  author={Rupert Kraus and Gerhard Spiteller and Wilfried Bartsch},
  year={1991}
}
(10E,12Z)-9-Hydroxy-10,12-octadecadienoic Acid, an Aromatase Inhibitor from Roots of Urtica dioica Aqueous-methanolic extracts from roots of Urtica dioica were fractionated and tested for aromatase-inhibition activity. After derivatization the most active fraction was separated by GC/ MS. Besides common fatty acids (10E,12Z)-9-hydroxy-10,12-octadecadienoic acid (1) was identified as a main component and confirmed to be the active principle. Lipoxygenase from tomatoes was used for synthesis… CONTINUE READING

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