(-)Deprenyl reduces delayed neuronal death of hippocampal pyramidal cells.

@article{Paterson1997DeprenylRD,
  title={(-)Deprenyl reduces delayed neuronal death of hippocampal pyramidal cells.},
  author={Ianthe Paterson and Alistair J. Barber and D L Gelowitz and Christopher Voll},
  journal={Neuroscience and biobehavioral reviews},
  year={1997},
  volume={21 2},
  pages={181-6}
}
Ischemia-induced delayed neuronal death can be mediated by apoptosis, and (-)deprenyl has been shown to block apoptosis in dopaminergic and cholinergic neurons. This study has investigated whether (-)deprenyl can prevent delayed neuronal death of hippocampal pyramidal cells. Rats were subjected to unilateral hypoxia-ischemia and treated with (-)deprenyl (0.25 mg/kg, s.c.) or saline daily. After sacrifice the left and right hippocampi were examined histologically. Unilateral delayed neuronal… CONTINUE READING
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