(-)-epigallocatechin gallate inhibits endothelin-1-induced C-reactive protein production in vascular smooth muscle cells.

@article{Wang2010epigallocatechinGI,
  title={(-)-epigallocatechin gallate inhibits endothelin-1-induced C-reactive protein production in vascular smooth muscle cells.},
  author={Chen-Jing Wang and Jun-tian Liu and Fang Guo},
  journal={Basic & clinical pharmacology & toxicology},
  year={2010},
  volume={107 2},
  pages={
          669-75
        }
}
Numerous studies have shown that C-reactive protein (CRP), a pro-inflammation cytokine, makes a direct contribution to atherosclerosis, and that (-)-epigallocatechin gallate (EGCG) is able to exert an anti-atherosclerotic effect by anti-oxidative and anti-inflammatory activities. Based on our previous study, the effect of EGCG on endothelin-1 (ET-1)-induced CRP production in rat vascular smooth muscle cells (VSMCs) and the possible mechanism were observed. The in vitro experiments showed that… CONTINUE READING
Highly Cited
This paper has 20 citations. REVIEW CITATIONS