(-)-Epigallocatechin gallate suppresses indoleamine 2,3-dioxygenase expression in murine dendritic cells: evidences for the COX-2 and STAT1 as potential targets.

@article{Jeong2007EpigallocatechinGS,
  title={(-)-Epigallocatechin gallate suppresses indoleamine 2,3-dioxygenase expression in murine dendritic cells: evidences for the COX-2 and STAT1 as potential targets.},
  author={Young-Il Jeong and In Duk Jung and Jun Sik Lee and Chang-Min Lee and Jae-Dong Lee and Y K Park},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={354 4},
  pages={1004-9}
}
(-)-Epigallocatechin gallate (EGCG), a major form of tea catechin, is suggested to exhibit antioxidant and anticyclooxygenase properties. Indoleamine 2,3-dioxygenase (IDO), as a key enzyme in T cell suppression and induction of immune tolerance to tumor, is expressed in various cell types. In the present study, we investigated whether EGCG could suppress the expression of IDO in murine bone marrow-derived dendritic cells (BMDCs) stimulated with IFN-gamma. We obtained evidence that EGCG… CONTINUE READING

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