(-)-Epigallocatechin gallate inhibits the expression of indoleamine 2,3-dioxygenase in human colorectal cancer cells.

@article{Ogawa2012EpigallocatechinGI,
  title={(-)-Epigallocatechin gallate inhibits the expression of indoleamine 2,3-dioxygenase in human colorectal cancer cells.},
  author={Kengo Ogawa and Takeshi Hara and Masahito Shimizu and Junji Nagano and Tomohiko Ohno and Masato Hoshi and Hiroyasu Ito and Hisashi Tsurumi and Kuniaki Saito and Mitsuru Seishima and Hisataka Moriwaki},
  journal={Oncology letters},
  year={2012},
  volume={4 3},
  pages={546-550}
}
Immune escape, the ability of tumor cells to avoid tumor-specific immune responses, occurs during the development and progression of several types of human malignancies, including colorectal cancer (CRC). Indoleamine 2,3-dioxygenase (IDO), the tryptophan catabolic enzyme, plays a significant role in regulating the immune response and provides tumor cells with a potent tool to evade the immune system. In the present study, we examined the effects of (-)-epigallocatechin gallate (EGCG), the major… CONTINUE READING

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