(-)-Epigallocatechin gallate inhibition of osteoclastic differentiation via NF-kappaB.

  title={(-)-Epigallocatechin gallate inhibition of osteoclastic differentiation via NF-kappaB.},
  author={R Lin and Chung-Hwan Chen and Yan-Hsiung Wang and M Ho and S H Hung and Ih-Sheng Chen and G. J. Wang},
  journal={Biochemical and biophysical research communications},
  volume={379 4},
People who regularly drink tea have been found to have a higher bone mineral density (BMD) and to be at less risk of hip fractures than those who do not drink it. Green tea catechins such as (-)-epigallocatechin gallate (EGCG) have been reported to increase osteogenic functioning in mesenchymal stem cells. However, its effect on osteoclastogenesis remains unclear. In this study, we investigated the effect of EGCG on RANKL-activation osteoclastogenesis and NF-kappaB in RAW 264.7, a murine… CONTINUE READING
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