(-)-Epigallocatechin-3-gallate suppresses osteoclast differentiation and ameliorates experimental arthritis in mice.

@article{Morinobu2008Epigallocatechin3gallateSO,
  title={(-)-Epigallocatechin-3-gallate suppresses osteoclast differentiation and ameliorates experimental arthritis in mice.},
  author={Akio Morinobu and Wang Biao and Shino Tanaka and Marika Horiuchi and Liu Jun and Goh Tsuji and Yoshitada Sakai and Masahiro Kurosaka and Shunichi Kumagai},
  journal={Arthritis and rheumatism},
  year={2008},
  volume={58 7},
  pages={2012-8}
}
OBJECTIVE To verify the effects of (-)-epigallocatechin-3-gallate (EGCG) on osteoclast differentiation and on experimental arthritis in mice. METHODS Human osteoclasts were differentiated from peripheral blood monocytes. The effects of EGCG were examined by tartrate-resistant acid phosphatase (TRAP) staining, bone resorption assay, Western blotting, and quantitative real-time polymerase chain reaction. Arthritis was induced in mice by injecting a cocktail of monoclonal antibodies against… CONTINUE READING
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