(-)-Epigallocatechin-3-gallate induces apoptosis in gastric cancer cell lines by down-regulating survivin expression.

@article{Onoda2011Epigallocatechin3gallateIA,
  title={(-)-Epigallocatechin-3-gallate induces apoptosis in gastric cancer cell lines by down-regulating survivin expression.},
  author={Chihiro Onoda and Kageaki Kuribayashi and Shinya Nirasawa and Naoki Tsuji and Maki Tanaka and Daisuke Kobayashi and Naoki Watanabe},
  journal={International journal of oncology},
  year={2011},
  volume={38 5},
  pages={
          1403-8
        }
}
The polyphenol (-)-epigallocatechin-3-gallate (EGCG) is a green tea constituent, which has been shown to inhibit cancer cell growth in vitro, in vivo and in epidemiological studies. In this study, we investigated its effects in gastric cancer cell lines. Five gastric cancer cell lines, the MKN-1, MKN-28, MKN-45, NUGC-3 and TMK-1, were found to be sensitive to EGCG treatment. Of all the cell lines tested, NUGC-3 was the most sensitive. EGCG treatment of NUGC-3 cells induced apoptosis, which was… 
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It is suggested that EGCG induced A549 lung cancer cell apoptosis in vivo, and had less toxic effects compared to classical anticancer drugs, and this is the first study demonstrating that the induction of apoptosis by EGCGs may be caused by the downregulation of Ku70 and that E GCG disrupts the interaction betweenKu70 and Bax in lung cancer.
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It is shown that LMB produces ROS and is possibly metabolized by CYP3A4, GPX1, and SOD in A549 cells, and combination treatment of LMB and EGCG augments LMB-induced cytotoxicity through enhanced ROS production and the modulation of drug metabolism and p21/survivin pathways.
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Epigallocatechin-3-gallate promotes apoptosis and expression of the caspase 9a splice variant in PC3 prostate cancer cells.
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The ability of the anticancer drug cisplatin to promote apoptosis was enhanced by EGCG and the expression of the pro-apoptotic splice isoform of caspase 9 was promoted.
Potential Therapeutic Targets of Epigallocatechin Gallate (EGCG), the Most Abundant Catechin in Green Tea, and Its Role in the Therapy of Various Types of Cancer
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Therapeutic implication of EGCG in cancer management and the mechanisms of action are discussed with an emphasis on human clinical trials.
(-)-Epigallocatechin-3-gallate Modulates the Differential Expression of Survivin Splice Variants and Protects Spermatogenesis During Testicular Torsion
  • N. Al-ajmi, M. Al-Maghrebi, W. Renno
  • Biology
    The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology
  • 2013
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The data indicate that EGCG protects the testis from TT/D-induced damage by protecting the morphology of the seminiferous tubules and modulating survivin 140 expression.
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It was observed that TBMS1 inhibited B GC823 gastric cancer cell proliferation in a concentration- and time-dependent manner and induced apoptosis by regulation of the Bcl-2 gene family in BGC823 cells.
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