(-)-Epigallocatechin-3-gallate ameliorates photodynamic therapy responses in an in vitro T lymphocyte model.

@article{Qi2014Epigallocatechin3gallateAP,
  title={(-)-Epigallocatechin-3-gallate ameliorates photodynamic therapy responses in an in vitro T lymphocyte model.},
  author={Hang Qi and Naomi Abe and Beiwei Zhu and Yoshiyuki Murata and Yoshimasa Nakamura},
  journal={Phytotherapy research : PTR},
  year={2014},
  volume={28 10},
  pages={1486-91}
}
(-)-Epigallocatechin-3-gallate (EGCG), the most abundant polyphenolic constituent in green tea, is known as a powerful antioxidant but concomitantly possesses a prooxidant property. We investigated the effect of EGCG on phloxine B (PhB)-induced photocytotoxicity in human T lymphocytic leukemia Jurkat cells. EGCG significantly potentiated PhB-induced photocytotoxic effects, including the inhibition of cell proliferation, DNA fragmentation, and caspase-3 activity induction in Jurkat cells… CONTINUE READING