(-)-Epicatechin mitigates high-fructose-associated insulin resistance by modulating redox signaling and endoplasmic reticulum stress.

@article{Bettaieb2014EpicatechinMH,
  title={(-)-Epicatechin mitigates high-fructose-associated insulin resistance by modulating redox signaling and endoplasmic reticulum stress.},
  author={Ahmed Bettaieb and Marcela Alejandra Vazquez Prieto and Cecilia Rodr{\'i}guez Lanzi and Roberto Miguel Miatello and Fawaz G. Haj and Cesar G Fraga and Patricia I. Oteiza},
  journal={Free radical biology & medicine},
  year={2014},
  volume={72},
  pages={
          247-56
        }
}
We investigated the capacity of dietary (-)-epicatechin (EC) to mitigate insulin resistance through the modulation of redox-regulated mechanisms in a rat model of metabolic syndrome. Adolescent rats were fed a regular chow diet without or with high fructose (HFr; 10% w/v) in drinking water for 8 weeks, and a group of HFr-fed rats was supplemented with EC in the diet. HFr-fed rats developed insulin resistance, which was mitigated by EC supplementation. Accordingly, the activation of components… CONTINUE READING

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