(-)-D-Deprenyl attenuates apoptosis in experimental brain ischaemia.

@article{Simon2001DDeprenylAA,
  title={(-)-D-Deprenyl attenuates apoptosis in experimental brain ischaemia.},
  author={L{\'a}szl{\'o} Simon and G{\'e}za Szil{\'a}gyi and Zolt{\'a}n Bori and P Orbay and Zolt{\'a}n K{\'a}roly Nagy},
  journal={European journal of pharmacology},
  year={2001},
  volume={430 2-3},
  pages={235-41}
}
(-)-D-Deprenyl protects neurons from oxidative damage and helps to maintain the mitochondrial membrane potential by influencing intracellular anti-apoptotic oncoproteins, such as Bcl-2. The cellular rescue in the penumbra region by (-)-D-deprenyl administration was examined after permanent middle cerebral artery occlusion in rats. (-)-D-Deprenyl was given continuously following permanent middle cerebral artery occlusion. Two days later, the rats were killed and their infarct volumes were… CONTINUE READING

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