(−)-Epigallocatechin-3-Gallate Ameliorates Learning and Memory Deficits by Adjusting the Balance of TrkA/p75NTR Signaling in APP/PS1 Transgenic Mice

@inproceedings{Liu2013Epigallocatechin3GallateAL,
  title={(−)-Epigallocatechin-3-Gallate Ameliorates Learning and Memory Deficits by Adjusting the Balance of TrkA/p75NTR Signaling in APP/PS1 Transgenic Mice},
  author={Mingyan Liu and Fujun Chen and Lei Sha and Shuang Wang and Lin Tao and Lutian Yao and Miao He and Zhimin Jamie Yao and Hang Liu and Zheng Zhu and Zhenjie Zhang and Zhihong Zheng and Xianzheng Sha and Minjie Wei},
  booktitle={Molecular Neurobiology},
  year={2013}
}
Alzheimer's disease (AD) is pathologically characterized by deposition of β-amyloid (Aβ) peptides, which closely correlates with the balance of nerve growth factor (NGF)-related TrkA/p75NTR signaling. (−)-Epigallocatechin-3-gallate (EGCG) is used for prevention and treatment of many neurodegenerative diseases, including AD. However, whether the neuroprotective effects of EGCG treatment were via modulating the balance of TrkA/p75NTR signaling was still unknown. In this study, we found that EGCG… CONTINUE READING

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