(‐)‐hydroxycitric acid does not affect energy expenditure and substrate oxidation in adult males in a post‐absorptive state

@article{Kriketos1999hydroxycitricAD,
  title={(‐)‐hydroxycitric acid does not affect energy expenditure and substrate oxidation in adult males in a post‐absorptive state},
  author={A Kriketos and H C Thompson and Harry Greene and Jo Ann Hill},
  journal={International Journal of Obesity},
  year={1999},
  volume={23},
  pages={867-873}
}
OBJECTIVE: (−)‐Hydroxycitric acid ((−)‐HCA) is available as a herbal supplement, and promoted as a weight loss agent. It is hypothesized that (−)‐HCA can increase fat oxidation by inhibiting citrate lyase, an enzyme which plays a crucial role in energy metabolism during de novo lipogenesis. The indirect inhibition of the cytosolic pool of citrate by (−)‐HCA and the subsequent reduction in acetyl coenzyme A and oxaloacetate alters steps in the citric acid cycle that promote fat oxidation. The… CONTINUE READING
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