• Biology, Medicine
  • Published in
    The Journal of comparative…
    2012
  • DOI:10.1002/cne.23048

(±)3,4-methylenedioxymethamphetamine ("ecstasy") treatment modulates expression of neurotrophins and their receptors in multiple regions of adult rat brain.

@article{Hemmerle201234methylenedioxymethamphetamineT,
  title={(±)3,4-methylenedioxymethamphetamine ("ecstasy") treatment modulates expression of neurotrophins and their receptors in multiple regions of adult rat brain.},
  author={Ann M. Hemmerle and Jonathan W. Dickerson and Nicole R. Herring and Tori L. Schaefer and Charles V Vorhees and Michael T Williams and Kim B. Seroogy},
  journal={The Journal of comparative neurology},
  year={2012},
  volume={520 11},
  pages={
          2459-74
        }
}
(±)3,4-Methylenedioxymethamphetamine (MDMA), a widely used drug of abuse, rapidly reduces serotonin levels in the brain when ingested or administered in sufficient quantities, resulting in deficits in complex route-based learning, spatial learning, and reference memory. Neurotrophins are important for survival and preservation of neurons in the adult brain, including serotonergic neurons. In this study, we examined the effects of MDMA on the expression of brain-derived neurotrophic factor (BDNF… CONTINUE READING

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