(+)-Arisugacin A--computational evidence of a dual binding site covalent inhibitor of acetylcholinesterase.

Abstract

A computation docking study of the highly potent, non-nitrogen containing, acetylcholinesterase inhibitor (+)-arisugacin A is presented. The model suggests that (+)-arisugacin A is a dual binding site covalent inhibitor of AChE. These findings are examined in the context of Alzheimer's disease-modifying therapeutic design. (+)-Arisugacin A's revealed mode… (More)
DOI: 10.1016/j.bmcl.2010.12.041

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