'Turn On/Off' fluorescence probe for the screening of unactivated Bruton's tyrosine kinase.

Abstract

BTK has emerged as a promising target for treating B-cell malignancies and autoimmune diseases, and there has been a growing demand to identify selective BTK inhibitors efficiently. In this Letter, we have designed and synthesized a new fluorescent probe to screen compounds that preferentially bind to an unactivated state of BTK (BTK [U]). The fluorescence… (More)
DOI: 10.1016/j.bmcl.2015.03.063

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