'Sealing off the CNS': cellular and molecular regulation of blood-brain barriergenesis.

@article{Siegenthaler2013SealingOT,
  title={'Sealing off the CNS': cellular and molecular regulation of blood-brain barriergenesis.},
  author={Julie A. Siegenthaler and Fabien Sohet and Richard Daneman},
  journal={Current opinion in neurobiology},
  year={2013},
  volume={23 6},
  pages={1057-64}
}
From their initial ingression into the neural tube to the established, adult vascular plexus, blood vessels within the CNS are truly unique. Covered by a virtually continuous layer of perivascular cells and astrocytic endfeet and connected by specialized cell-cell junctional contacts, mature CNS blood vessels simultaneously provide nutritive blood flow and protect the neural milieu from potentially disruptive or harmful molecules and cells flowing through the vessel lumen. In this review we… CONTINUE READING

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