'Quantal' Ca2+ release and the control of Ca2+ entry by inositol phosphates--a possible mechanism.

@article{Irvine1990QuantalCR,
  title={'Quantal' Ca2+ release and the control of Ca2+ entry by inositol phosphates--a possible mechanism.},
  author={Robin F. Irvine},
  journal={FEBS letters},
  year={1990},
  volume={263 1},
  pages={5-9}
}
The release of Ca2+ from intracellular stores by sub-optimal doses of inositol trisphosphate has been shown to be dose-related ('quantal'), and a simple model is proposed here to account for this phenomenon. It is suggested that there is a regulatory Ca2(+)-binding site on, or associated with, the luminal domain of the InsP3 receptor, which allosterically controls Ca2+ efflux, and the affinity for Ca2+ of that site is modulated by InsP3 binding to the cytoplasmic domain of the receptor; a… CONTINUE READING