'Normal' semantic-phonemic fluency discrepancy in Alzheimer's disease? A meta-analytic study.

  title={'Normal' semantic-phonemic fluency discrepancy in Alzheimer's disease? A meta-analytic study.},
  author={Keith R. Laws and Amy Duncan and Tim M. Gale},
  journal={Cortex; a journal devoted to the study of the nervous system and behavior},
  volume={46 5},
In a meta-analysis of 135 studies involving 6000 patients with Alzheimer's disease (AD) and 6057 healthy controls, we examined the relative degree of semantic and phonemic fluency impairment in AD patients. The effect size for semantic fluency (d=2.10: 95%CI 2.22-1.97) was significantly larger than for both phonemic fluency (d=1.46: 95%CI 1.56-1.36) and picture naming (d=1.54: 95%CI 1.66-1.40). In meta-regression analyses we found that studies with greater proportions of female patients and… CONTINUE READING


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