'Natively unfolded' nucleoporins in nucleocytoplasmic transport: clustered or evenly distributed?

@article{Yang2011NativelyUN,
  title={'Natively unfolded' nucleoporins in nucleocytoplasmic transport: clustered or evenly distributed?},
  author={Weidong Yang},
  journal={Nucleus},
  year={2011},
  volume={2 1},
  pages={10-6}
}
The nuclear pore complex (NPC) acts as a selective gate that mediates the bidirectional transport of macromolecules between the cytoplasm and the nucleus of eukaryotic cells. 'Natively unfolded' nucleoporins (Nups) with domains rich in phenylalanine-glycine (FG) repeats form the selective permeability barrier and provide binding sites for mobile transport receptors in the NPC. Understanding the structure and function of the FG-Nups barrier under real-time trafficking conditions is still a… CONTINUE READING
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