'It's the way that you look at it'--a cognitive neuropsychological account of SSRI action in depression.

@article{Harmer2013ItsTW,
  title={'It's the way that you look at it'--a cognitive neuropsychological account of SSRI action in depression.},
  author={Catherine J. Harmer and Philip J. Cowen},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={2013},
  volume={368 1615},
  pages={20120407}
}
The fact that selective serotonin reuptake inhibitors (SSRIs) have antidepressant effects in some patients supports the notion that serotonin plays a role in the mode of action of antidepressant drugs. However, neither the way in which serotonin may alleviate depressed mood  nor the reason why several weeks needs to elapse before the full antidepressant effect of treatment is expressed  is known. Here, we propose a neuropsychological theory of SSRI antidepressant action based on the ability of… CONTINUE READING