'Ischemic tolerance' phenomenon found in the brain.

  title={'Ischemic tolerance' phenomenon found in the brain.},
  author={Kazuo Kitagawa and Mishiya Matsumoto and Masafumi Tagaya and Ruyji Hata and Hiroshi Ueda and Michio Niinobe and N. Handa and Ryuzo Fukunaga and Kiyoshi Kimura and Katsuhiko Mikoshiba},
  journal={Brain research},
  volume={528 1},
We investigated the possibility that neuronal cells given a mild ischemic treatment sufficient to perturb the cellular metabolism acquired tolerance to a subsequent, and what would be lethal, ischemic stress in vivo. Cerebral ischemia was produced in the gerbils by occlusion of both common carotids for 5 min, which consistently resulted in delayed neuronal death in the CA1 region of the hippocampus. Minor 2-min ischemia in this model depletes high-energy phosphate compounds and perturbs the… CONTINUE READING
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