'Insulin autoantibody affinity measurement using a single concentration of unlabelled insulin competitor discriminates risk in relatives of patients with type 1 diabetes.

@article{Curnock2012InsulinAA,
  title={'Insulin autoantibody affinity measurement using a single concentration of unlabelled insulin competitor discriminates risk in relatives of patients with type 1 diabetes.},
  author={Rachel Curnock and Charles Reed and Saba Rokni and Jack Broadhurst and Polly J. Bingley and A J K Williams},
  journal={Clinical and experimental immunology},
  year={2012},
  volume={167 1},
  pages={67-72}
}
Development of high-risk combinations of multiple islet autoantibodies and type 1 diabetes is associated with high-affinity insulin autoantibodies (IAA), but IAA affinity measurements require large serum volumes. We therefore investigated whether a simplified method of IAA affinity measurement using a low concentration of unlabelled insulin (ULI) competitor discriminated between moderate-high- and low-affinity IAA and identified individuals at highest risk of disease. Samples were assayed by… CONTINUE READING
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