• Corpus ID: 4261161

'I'm Sober, Doctor, Really': Best Biomarkers for Underreported Alcohol Use: When and How to Use Highly Specific Combinations to Assess Withdrawal Risk

  title={'I'm Sober, Doctor, Really': Best Biomarkers for Underreported Alcohol Use: When and How to Use Highly Specific Combinations to Assess Withdrawal Risk},
  author={David R. Spiegel and Neetu Dhadwal and Frances Gill},
  journal={Current psychiatry},
Hospitalized patients who are not truthful about their alcohol consumption may be at risk for an unplanned withdraw. Self-reports of alcohol use--such as CAGE and the Alcohol Use Disorders Identification Test (AUDIT)--are valid, inexpensive, and noninvasive, but patients easily can feign results. (1) Biochemical measures are more objective, and combinations of markers are an effective tool to detect recent heavy drinking in the 10% to 25% of patients who underreport alcohol use. (2… 
7 Citations

Tables from this paper

Biomarkers of alcohol misuse: recent advances and future prospects
The issue of alcohol biomarker definition, the types of molecules used as so-called traditional biomarkers, and the compounds that can serve as novel biomarker candidates or components of biomarker panels are addressed.
Absolute Abstinence as a Treatment Outcome in Servicemen with Alcohol Dependence: A Retrospective Cohort Study
Early absolute abstinence emerged as an actionable objective and an achievable goal without any contributory socio-demographic predilections and is a tenable and realistic target of current ADS treatment programs.
Gamma-Glutamyl Transferase: A Useful Marker of Habitual Drinking in Cases of Alcohol-Associated Osteonecrosis of the Femoral Head.
Serum GGT level is a useful laboratory marker with moderate accuracy that indicates habitual drinking in patients with alcohol-associated ONFH.
How to Manage Medical Complications of the 5 Most Abused Substances: Monitor for Symptoms and Lab Findings That Indicate Risk of Serious Consequences
An overview of common medical complications related to using alcohol, marijuana, cocaine, methamphetamines, and opioids is provided.


The Use of a Combination of Peripheral Markers for Diagnosing Alcoholism and Monitoring for Continued Abuse
Values for serum aspartate transaminase, gamma glutamyl transpeptidase and mean corpuscular volume were followed in twenty actively drinking alcoholics with pre-cirrhotic liver disease over a
Carbohydrate-deficient transferrin and conventional alcohol markers as indicators for brief intervention among heavy drinkers in primary health care.
Diagnostic value of carbohydrate-deficient transferrin (CDT), mean corpuscular volume (MCV), aspartate aminotransferase (AST), alanine aminodiazepine (ALT), and gamma-glutamyltransferase (GGT) in detecting early-phase heavy drinkers for brief intervention treatment in primary health care is examined.
Comparison of the combined marker GGT-CDT and the conventional laboratory markers of alcohol abuse in heavy drinkers, moderate drinkers and abstainers.
GGT-CDT improves the sensitivity of detecting excessive ethanol consumption as compared with the traditional markers of ethanol consumption, and should be considered in the assessment of patients with alcohol use disorders.
Superiority of carbohydrate-deficient transferrin to gamma-glutamyltransferase in detecting relapse in alcoholism.
Carohydrate-deficient transferrin proved to be superior to gamma-glutamyltransferase in relapse detection in an outpatient care setting for alcoholics, and was especially useful in detecting early relapses during the initial rehabilitation phase.
Longitudinal comparison of carbohydrate-deficient transferrin and gamma-glutamyl transferase: complementary markers of excessive alcohol consumption.
The present results indicate that measurement of both CDT and GGT will increase the possibility of identifying excessive alcohol consumption and allows for improved detection of relapse into heavy drinking during long-term monitoring of out-patients.
Serum carbohydrate-deficient transferrin as a marker of alcohol consumption in patients with chronic liver diseases.
Serum CDT seems to be a better indicator of abstention than GGT; AST; AST and MCV in patients with alcoholic liver disease, however, in the hands CDT is not so sensitive for alcohol abuse in Patients with liver disease as reported earlier in unselected alcoholics.