'Fetal-type' B and T lymphocytes in rheumatoid arthritis and primary Sjögren's syndrome.

Abstract

B lymphocytes expressing CD5 (CD5+B cells) and T lymphocytes using the gamma and delta chains to form their antigen receptor (gamma delta +T cells) are major populations in developing fetuses, but become relatively minor in normal adults. However, both subsets are expanded in the peripheral blood of more than 50% of patients with rheumatoid arthritis and… (More)

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