'Early' mammalian myoblasts are resistant to phorbol ester-induced block of differentiation.

@article{Cossu1988EarlyMM,
  title={'Early' mammalian myoblasts are resistant to phorbol ester-induced block of differentiation.},
  author={Giulio Cossu and Giulia Ranaldi and Michele Senni and Mario Molinaro and Elisabetta Vivarelli},
  journal={Development},
  year={1988},
  volume={102 1},
  pages={65-9}
}
Mesenchymal cells were isolated from somites and limbs of mouse embryos at different developmental stages. When grown in tissue culture, some of the cells underwent muscle differentiation as indicated by synthesis of sarcomeric myosin, acetylcholine receptor and, in the case of limb cells, fusion into multinucleated myotubes. When the tumour promoter 12-O-tetradecanoyl phorbol 13-acetate (TPA) was added to these cultures, it caused differential effects, depending upon the age of the embryo from… CONTINUE READING

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