'Compulsive' lever-pressing in rats is attenuated by the serotonin re-uptake inhibitors paroxetine and fluvoxamine but not by the tricyclic antidepressant desipramine or the anxiolytic diazepam.

@article{Joel2004CompulsiveLI,
  title={'Compulsive' lever-pressing in rats is attenuated by the serotonin re-uptake inhibitors paroxetine and fluvoxamine but not by the tricyclic antidepressant desipramine or the anxiolytic diazepam.},
  author={Daphna Joel and E Ben-Amir and Julia T Doljansky and S Flaisher},
  journal={Behavioural pharmacology},
  year={2004},
  volume={15 3},
  pages={241-52}
}
Rats undergoing extinction of lever-pressing for food after the attenuation of an external feedback for this behavior, exhibit excessive lever-pressing unaccompanied by an attempt to collect a reward, which may be analogous to the excessive and unreasonable behavior seen in obsessive-compulsive disorder (OCD). Given that one of the most salient features of OCD is its selective response to treatment with serotonin re-uptake inhibitors (SRIs), the present study compared the effects of the SRIs… CONTINUE READING
35 Citations
77 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 77 references

Historical considerations

  • RK Pitman
  • In: Zohar J, Insel T, Rasmussen S (editors): The…
  • 1991
Highly Influential
4 Excerpts

Neuroethological models of obsessive–compulsive disorder

  • JT Winslow, TR Insel
  • 1991
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…