'Click' D(1) receptor agonists with a 5-HT(1A) receptor pharmacophore producing D(2) receptor activity.

@article{Zhang2009ClickDR,
  title={'Click' D(1) receptor agonists with a 5-HT(1A) receptor pharmacophore producing D(2) receptor activity.},
  author={Jing Zhang and Hai Zhang and Wenxian Cai and Leiping Yu and Xuechu Zhen and Ao Zhang},
  journal={Bioorganic & medicinal chemistry},
  year={2009},
  volume={17 14},
  pages={
          4873-80
        }
}
A series of new 1-aryl-3-benzazepine derivatives containing an arylpiperazinyl function as the N3 substituent were synthesized by combining a D(1) receptor agonistic pharmacophore and a 5-HT(1A) receptor pharmacophore through Click reaction. Interestingly, these compounds generally do not have good binding affinity at the D(1) receptor, but most compounds are potent at both D(2) and 5-HT(1A) receptors. Compound 8h, containing 1-m-tolyl-benzazepine scaffold and 2-methoxyphenylpiperazine core… CONTINUE READING
BETA