'Bystander killing' induces apoptosis and is inhibited by forskolin.

'Bystander killing' is a term used to describe the broad cell death associated with the transduction of the herpes simplex virus thymidine kinase gene (HSV1-tk) and administration of nucleoside analogs and which extends the killing effect to adjacent cells not transduced with HSV1-tk ('bystander cells'). HSV1-tk negative cells can be killed by co-culture… (More)