"Wide-open" 1.3 A structure of a multidrug-resistant HIV-1 protease as a drug target.

@article{Martin2005Wideopen1A,
  title={"Wide-open" 1.3 A structure of a multidrug-resistant HIV-1 protease as a drug target.},
  author={Philip D. Martin and John F Vickrey and Gheorghe Proteasa and Yurytzy L{\'o}pez Jim{\'e}nez and Zdzislaw Wawrzak and Mark A. Winters and Thomas C. Merigan and Ladislau C. Kovari},
  journal={Structure},
  year={2005},
  volume={13 12},
  pages={1887-95}
}
This report examines structural changes in a highly mutated, clinical multidrug-resistant HIV-1 protease, and the crystal structure has been solved to 1.3 A resolution in the absence of any inhibitor. This protease variant contains codon mutations at positions 10, 36, 46, 54, 62, 63, 71, 82, 84, and 90 that confer resistance to protease inhibitors. Major differences between the wild-type and the variant include a structural change initiated by the M36V mutation and amplified by additional… CONTINUE READING

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