"Viable motheaten," a new allele at the motheaten locus. I. Pathology.

@article{Shultz1984ViableMA,
  title={"Viable motheaten," a new allele at the motheaten locus. I. Pathology.},
  author={Leonard D Shultz and D. R. Coman and C L Bailey and Wesley G. Beamer and Charles L. Sidman},
  journal={The American journal of pathology},
  year={1984},
  volume={116 2},
  pages={179-92}
}
A new spontaneous autosomal recessive mutation has recently occurred at the motheaten (me) locus on Chromosome 6 in strain C57BL/6J mice. Homozygotes for the new allele, designated "viable motheaten" (mev), have a mean life span of 61 +/- 2.4 days, compared with only 22 +/- 1.3 days for C57BL/6J-me/me mice. Like the original motheaten mutation, the immediate cause of death in mev/mev mice appears to be severe pneumonitis associated with accumulations of macrophages, granulocytes, and… CONTINUE READING