"Two out of three": an alternative method for codon reading.

  title={"Two out of three": an alternative method for codon reading.},
  author={Ulf Lagerkvist},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={75 4},
  • Ulf Lagerkvist
  • Published 1978 in
    Proceedings of the National Academy of Sciences…
An alternative method for codon reading, whereby only the first two codon nucleotides are recognized by the anticodon, is discussed and the experimental evidence for this "two of three" reading method is reviewed. Misreading of codons by the "two out of three" method could pose a significant threat to the fidelity of protein synthesis unless the genetic code is organized in such a way as to prevent this method from being used when it might compromise translational fidelity. Inspection of the… CONTINUE READING

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J . Biol . Chem . 252 , 471 - 478

  • S. K. Mitra, F. Lustig, B. Akesson, U. Lagerkvist
  • 1977

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