"Tissue" transglutaminase contributes to the formation of disulphide bridges in proteins of mitochondrial respiratory complexes.

@article{Mastroberardino2006TissueTC,
  title={"Tissue" transglutaminase contributes to the formation of disulphide bridges in proteins of mitochondrial respiratory complexes.},
  author={Pier G. Mastroberardino and Maria Grazia Farrace and Irene Viti and Flaminia Pavone and Gian Maria Fimia and Gennaro Melino and Carlo Rodolfo and Mauro Piacentini},
  journal={Biochimica et biophysica acta},
  year={2006},
  volume={1757 9-10},
  pages={
          1357-65
        }
}
In this study we provide the first in vivo evidences showing that, under physiological conditions, "tissue" transglutaminase (TG2) might acts as a protein disulphide isomerase (PDI) and through this activity contributes to the correct assembly of the respiratory chain complexes. Mice lacking TG2 exhibit mitochondrial energy production impairment, evidenced by decreased ATP levels after physical challenge. This defect is phenotypically reflected in a dramatic decrease of motor behaviour of the… CONTINUE READING
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