"Thick" cell membranes revealed by immunocytochemical staining: a clue to the diagnosis of mesothelioma.

@article{Leong1990ThickCM,
  title={"Thick" cell membranes revealed by immunocytochemical staining: a clue to the diagnosis of mesothelioma.},
  author={Anthony S-y Leong and Robert Parkinson and James Milios},
  journal={Diagnostic cytopathology},
  year={1990},
  volume={6 1},
  pages={9-13}
}
The distinction of malignant mesothelioma from metastatic adenocarcinoma in pleural effusions and biopsies is frequently a diagnostic problem. Immunocytochemical staining of 13 malignant mesotheliomas, eight primary adenocarcinomas of the lung, five metastatic adenocarcinomas of the lung, and 20 primary adenocarcinomas in extrapulmonary sites with a monoclonal antibody to epithelial membrane antigen (EMA) revealed "thick" cell membranes in all cases of mesothelioma. This distinctive pattern of… CONTINUE READING