"Therapeutic" serum concentration of phenytoin: the influence of seizure type.

  title={"Therapeutic" serum concentration of phenytoin: the influence of seizure type.},
  author={Douglass Matthew Turnbull and Michael D Rawlins and David Weightman and D. W. Chadwick},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  volume={47 3},
Serum phenytoin concentrations were monitored prospectively in 26 patients with previously untreated partial epilepsy, during monotherapy with phenytoin. Only six remained entirely seizure-free, although only four experienced further tonic-clonic seizures. There was no correlation between serum phenytoin concentrations and freedom from partial seizures in those patients in whom such seizures recurred. There did appear to be a correlation between serum phenytoin concentration and freedom from… CONTINUE READING

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