"Teflon-coated peptides": hexafluoroacetone trihydrate as a structure stabilizer for peptides.

@article{Rajan1997TefloncoatedPH,
  title={"Teflon-coated peptides": hexafluoroacetone trihydrate as a structure stabilizer for peptides.},
  author={Roshini Rajan and Sanjay K. Awasthi and Surajit Bhattacharjya and Padmanabhan Balaram},
  journal={Biopolymers},
  year={1997},
  volume={42 2},
  pages={
          125-8
        }
}
In the last 30 years, since the early work of Goodman and co-workers introducing trifluoroethanol as a solvent in peptide conformational analysis,1,2 the ability of fluoroalcohols to stabilize secondary structures in peptides in aqueous solution is well documented.3–7 However, the detailed molecular mechanisms remain to be understood. 3,4,8–12 2,2,2-Trifluoroethanol (TFE) has been the most widely used fluoroalcohol additive to aqueous solutions of peptides and proteins.4,13–18 We describe in… CONTINUE READING
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