"Targeting the absence" and therapeutic engineering for cancer therapy.

  title={"Targeting the absence" and therapeutic engineering for cancer therapy.},
  author={Mikhail V. Blagosklonny},
  journal={Cell cycle},
  volume={7 10},
The Gotham Prize was awarded to Alex Varshavsky for "Targeting the absence", a strategy employing negative targets of cancer therapy. This is a brilliant example of therapeutic engineering: designing a sequence of events that leads to the selective killing of one type of cell, while sparing all others. A complex molecular device (Varshavsky's Demon) examines DNA, recognizes the present target in normal cells and kills cancer cells. The strategy is limited by the delivery (transfection or… CONTINUE READING

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