"Superhumanized" antibodies: reduction of immunogenic potential by complementarity-determining region grafting with human germline sequences: application to an anti-CD28.

@article{Tan2002SuperhumanizedAR,
  title={"Superhumanized" antibodies: reduction of immunogenic potential by complementarity-determining region grafting with human germline sequences: application to an anti-CD28.},
  author={Philip Tan and David Alexander Mitchell and Timothy N. Buss and Margaret A. Holmes and Claudio Anasetti and Jefferson Foote},
  journal={Journal of immunology},
  year={2002},
  volume={169 2},
  pages={1119-25}
}
Humanized Abs are created by combining, at the genetic level, the complementarity-determining regions of a murine mAb with the framework sequences of a human Ab variable domain. This leads to a functional Ab with reduced immunogenic side effects in human therapy. In this study, we report a new approach to humanizing murine mAbs that may reduce immunogenicity even further. This method is applied to humanize the murine anti-human CD28 Ab, 9.3. The canonical structures of the hypervariable loops… CONTINUE READING

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