"Stepping-up" from methotrexate: a systematic review of randomised placebo controlled trials in patients with rheumatoid arthritis with an incomplete response to methotrexate.

@article{Hochberg2001SteppingupFM,
  title={"Stepping-up" from methotrexate: a systematic review of randomised placebo controlled trials in patients with rheumatoid arthritis with an incomplete response to methotrexate.},
  author={Marc C. Hochberg and J. Kathleen Tracy and Raymond Flores},
  journal={Annals of the rheumatic diseases},
  year={2001},
  volume={60 Suppl 3},
  pages={
          iii51-4
        }
}
Methotrexate is presently the standard disease modifying antirheumatic drug (DMARD) for patients with active rheumatoid arthritis (RA). Despite its short term eYcacy in clinical trials and long term eVectiveness in clinical practice, many patients continue to have signs and symptoms of active disease while taking a maximally tolerated dose. Over the past decade there has been increasing interest in the use of combination therapy in patients with RA. Boers and Ramsden published the first… CONTINUE READING

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