"Smart" delivery of antisense oligonucleotides by anionic pH-sensitive liposomes.

@article{Fattal2004SmartDO,
  title={"Smart" delivery of antisense oligonucleotides by anionic pH-sensitive liposomes.},
  author={Elias Fattal and Patrick Couvreur and Catherine Dubernet},
  journal={Advanced drug delivery reviews},
  year={2004},
  volume={56 7},
  pages={
          931-46
        }
}
Antisense oligonucleotides are molecules that are able to inhibit gene expression being, therefore, potentially active for the treatment of viral infections cancer or inflammatory diseases. However, because of their poor stability in biological medium and their weak intracellular penetration, "smart" delivery systems such as anionic pH-sensitive liposomes were designed. Most known liposome formulations contain a specific phospholipid, phosphatidylethanolamine (PE), which undergoes a transition… CONTINUE READING
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