"Signal off" aptasensor based on enzyme inhibition induced by conformational switch.


A novel sensing strategy for electrochemical aptamer-based sensors is presented. Nucleic acid aptamers are considered alternatives to antibodies. However, some of their intrinsic properties, such as that they can undergo conformational changes during the binding of the target, can be used to design novel sensing strategies. Unlike other electrochemical… (More)
DOI: 10.1021/ac402258x