"Serotonin depression"--a biochemical subgroup within the affective disorders?

@article{sberg1976SerotoninDB,
  title={"Serotonin depression"--a biochemical subgroup within the affective disorders?},
  author={Marie {\AA}sberg and Peter Thor{\'e}n and L Tr{\"a}skman and Leif Bertilsson and V. A. Ringberger},
  journal={Science},
  year={1976},
  volume={191 4226},
  pages={478-80}
}
The distribution of 5-hydroxyindoleacetic acid (5-HIAA) concentrations in the cerebrospinal fluid of 68 depressed patients was bimodal. Twenty-nine percent of the patients were in the lower mode, with a concentration of 5-HIAA below 15 nanograms per milliliter. Although there were no differences in overall severity of depression between the two modes, there was a significant correlation between the concnetration of 5-HIAA and severity of depression in the lower, but not in the upper, mode. The… CONTINUE READING
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