"Ring-fencing" BRCA1 tumor suppressor activity.

@article{Patel2011RingfencingBT,
  title={"Ring-fencing" BRCA1 tumor suppressor activity.},
  author={K. Patel and Gerry P Crossan and Michael R G Hodskinson},
  journal={Cancer cell},
  year={2011},
  volume={20 6},
  pages={
          693-5
        }
}
BRCA1 is a crucial human breast and ovarian cancer tumor suppressor gene. The article by Drost et al. in this issue of Cancer Cell together with a recent paper in Science now provide a clearer picture of how this large and complex protein suppresses tumorigenesis. 
4 Citations
Allele-specific expression mediates primary resistance to poly (ADP-ribose) polymerase inhibitor therapy in a case of BRCA1/2 double-germline mutant gastric cancer
  • L. Wen, X. Li, +4 authors J. Guo
  • Medicine
  • The Journal of international medical research
  • 2019
  • PDF
BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1.
  • 65
  • PDF

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