"Ring-fencing" BRCA1 tumor suppressor activity.

  title={"Ring-fencing" BRCA1 tumor suppressor activity.},
  author={K. Patel and Gerry P Crossan and Michael R G Hodskinson},
  journal={Cancer cell},
  volume={20 6},
BRCA1 is a crucial human breast and ovarian cancer tumor suppressor gene. The article by Drost et al. in this issue of Cancer Cell together with a recent paper in Science now provide a clearer picture of how this large and complex protein suppresses tumorigenesis. 
4 Citations
Allele-specific expression mediates primary resistance to poly (ADP-ribose) polymerase inhibitor therapy in a case of BRCA1/2 double-germline mutant gastric cancer
  • L. Wen, X. Li, +4 authors J. Guo
  • Medicine
  • The Journal of international medical research
  • 2019
  • PDF
BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1.
  • 65
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BRCA1 and its toolbox for the maintenance of genome integrity
  • 446
  • PDF
BRCA1 Tumor Suppression Depends on BRCT Phosphoprotein Binding, But Not Its E3 Ligase Activity
  • 214
  • Highly Influential
BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance.
  • 192
  • Highly Influential
BRCA1 tumor suppression occurs via heterochromatin mediated silencing
  • 360
  • PDF
Cancer-predisposing mutations within the RING domain of BRCA1: Loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity
  • 362
  • PDF
E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks
  • 126
  • PDF
Structure of a BRCA1–BARD1 heterodimeric RING–RING complex
  • 422
BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair.
  • 267
  • PDF
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.
  • 3,015
  • PDF