"Reverse Genomics" Predicts Function of Human Conserved Noncoding Elements.

@article{Marcovitz2016ReverseGP,
  title={"Reverse Genomics" Predicts Function of Human Conserved Noncoding Elements.},
  author={Amir Marcovitz and Robin Jia and Gill Bejerano},
  journal={Molecular biology and evolution},
  year={2016},
  volume={33 5},
  pages={
          1358-69
        }
}
Evolutionary changes in cis-regulatory elements are thought to play a key role in morphological and physiological diversity across animals. [] Key Result We identify thousands of human CNEs that were lost in at least two independent mammalian lineages (IL-CNEs), and match their evolutionary profiles against a diverse set of phenotypes recently annotated across multiple mammalian species. We identify 2,759 compelling associations between human CNEs and a diverse set of mammalian phenotypes.

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