"Prevention of structural perturbation and aggregation of hepatitis B surface antigen: screening of various additives".


The instability of protein and antigen(s) during encapsulation in biodegradable polymers by water-in-oil-in-water (w/o/w) encapsulation is well established. The aim of present study is to screen various additives to prevent the inactivation and loss of immunogenicity of HBsAg upon its exposure to the water/CH(2)Cl(2) (methylene chloride) interface by… (More)
DOI: 10.3109/10837450.2010.546408


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