"Plugging into Enzymes": Nanowiring of Redox Enzymes by a Gold Nanoparticle

  title={"Plugging into Enzymes": Nanowiring of Redox Enzymes by a Gold Nanoparticle},
  author={Yi Xiao and F. Patolsky and Eugenii Katz and J. Hainfeld and I. Willner},
  pages={1877 - 1881}
  • Yi Xiao, F. Patolsky, +2 authors I. Willner
  • Published 2003
  • Chemistry, Medicine
  • Science
  • The reconstitution of an apo-flavoenzyme, apo–glucose oxidase, on a 1.4-nanometer gold nanocrystal functionalized with the cofactor flavin adenine dinucleotide and integrated into a conductive film yields a bioelectrocatalytic system with exceptional electrical contact with the electrode support. The electron transfer turnover rate of the reconstituted bioelectrocatalyst is ∼5000 per second, compared with the rate at which molecular oxygen, the natural cosubstrate of the enzyme, accepts… CONTINUE READING
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