"Plate cherry picking": a novel semi-sequential screening paradigm for cheaper, faster, information-rich compound selection.

@article{Crisman2007PlateCP,
  title={"Plate cherry picking": a novel semi-sequential screening paradigm for cheaper, faster, information-rich compound selection.},
  author={Thomas J. Crisman and Jeremy L. Jenkins and Christian N. Parker and William A. Hill and Andreas Bender and Zhan Deng and James H. Nettles and John W. Davies and Meir Glick},
  journal={Journal of biomolecular screening},
  year={2007},
  volume={12 3},
  pages={320-7}
}
This work describes a novel semi-sequential technique for in silico enhancement of high-throughput screening (HTS) experiments now employed at Novartis. It is used in situations in which the size of the screen is limited by the readout (e.g., high-content screens) or the amount of reagents or tools (proteins or cells) available. By performing computational… CONTINUE READING