"Physiological genomics": mutant screens in zebrafish.

  title={"Physiological genomics": mutant screens in zebrafish.},
  author={Kerri S. Warren and Mark C Fishman},
  journal={The American journal of physiology},
  volume={275 1 Pt 2},
Large-scale mutagenesis screens have proved essential in the search for genes that are important to development in the fly, worm, and yeast. Here we present the power of large-scale screening in a vertebrate, the zebrafish Danio rerio, and propose the use of this genetic system to address fundamental questions of vertebrate developmental physiology. As an example, we focus on zebrafish mutations that reveal single genes essential for normal development of the cardiovascular system. These single… CONTINUE READING