"Module" substitution in hemoglobin subunits. Preparation and characterization of a "chimera beta alpha-subunit".

@article{Wakasugi1994ModuleSI,
  title={"Module" substitution in hemoglobin subunits. Preparation and characterization of a "chimera beta alpha-subunit".},
  author={Keisuke Wakasugi and Koichiro Ishimori and Kiyohiro Imai and Yuko Wada and Isao Morishima},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 29},
  pages={18750-6}
}
In the genes of alpha- and beta-subunits of hemoglobin, Go showed that modules F1, F2 + F3, and F4 correspond to exons 1, 2, and 3, respectively (Go, M. (1981) Nature 291, 90). The analysis of the correlation of function with its exon pattern showed that the residues associated with the defined function are concentrated in the specific exons encoding the "module" (Eaton, W.A. (1980) Nature 284, 183). To investigate the functional and structural significance of the "modular structure," we… CONTINUE READING